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Recurrent Implantation Failure and Pregnancy Loss

Intracytoplasmic sperm injection (ICSI)

Intrauterine insemination (IUI)

Recurrent Pregnancy Implantation failure

Preimplantation Genetic Diagnosis/Screening

Hystroscopy & Laparoscopy Diagnostic Services

Recurrent implantation failure describes the inability of a woman under the age of 40 to conceive clinically following the transfer of at least four
high-quality embryos in at least three fresh or frozen cycles. Factors related to the uterus or the embryo may be the cause of the failure to implant.
Recurrent implantation failure (RIF) may pose a significant burden on a couple physically, emotionally, and financially.

Recurrent pregnancy loss (RPL), also known as recurrent miscarriage or chronic abortion, is traditionally understood as three successive pregnancies
lost before 20 weeks from the last menstrual cycle. Around 1-2% of women are experiencing recurrent miscarriages. Before going for another pregnancy
requires proper diagnostic testing and therapeutic intervention are recommended to treat the underlying cause and avoid the risk of subsequent fetal loss.

Uterine abnormalities, immunological conditions such as antiphospholipid syndrome, endocrine conditions, advanced maternal age, abnormality
in the uterus, and genetic disorders can all contribute to recurrent miscarriages.

How are the causes of RIF and recurrent pregnancy loss diagnosed?

At first, specialists at the infertility center will carry out a detailed medical, surgical, genetic, and family history followed by a physical examination.

Karyotype analysis is done to determine the chromosomal or genetic abnormalities in both partners that result in recurrent miscarriages. Evaluation of the uterus (womb) and uterus cavity is carried out using ultrasound, saline ultrasound, hysterosalpingogram X-ray, MRI, or hysteroscopy. These techniques help in determining the shape of the uterus as well as the presence of any abnormalities like fibroids, the location of fibroids, polyps, or scarring. Test for hormone function, antiphospholipid antibodies, abnormal blood clotting, and ovarian reserve test is also carried out to determine the underlying cause of fetal loss.

RIF and Recurrent Pregnancy Loss Treatment

Treatments available to alleviate the risk of fetal loss include:

1. Surgery:

Surgery can rectify concerns related to the uterus (womb), like correcting the uterus's size and removing Fibroids / septum/synechiae. The surgery procedure can be carried out in 1-day and takes around 1-week to recover.

2. Medications:

Conditions like autoimmune disorder, blood clotting issues, abnormal blood sugar levels, over or under-active thyroid gland, or high hormone prolactin levels can be treated with the right medications to prevent miscarriages.

3. Genetic Screening:

Preimplantation genetic screening (PGS), which evaluates for the existence of faulty genetic components by taking a biopsy from one cell of the embryo, is one approach that can help in choosing the most "capable" embryos for transfer. Time-lapse imaging makes it possible to monitor embryo development in real-time and choose the best embryos for implantation during In-vitro fertilization to prevent RIF.

Infertility specialists at Atharva Infertility Center specialize in managing the difficult cases of multiple failures by thorough use of scientific analysis, advanced diagnostic procedures, and specialized evidence-based care.