Introduction
Preimplantation Genetic Diagnosis (PGD), also known as Preimplantation Genetic Testing (PGT), is a state-of-the-art fertility procedure performed during an IVF cycle to screen embryos for genetic abnormalities before they are transferred into the uterus. This advanced screening helps couples:
- Reduce risk of chromosomal disorders
- Improve chance of successful pregnancy
- Prevent heritable genetic diseases
- Improve implantation outcomes
At Atharva Infertility Centre, Nashik, we integrate PGD/PGT with advanced IVF protocols using world-class genetic labs and expert reproductive specialists. This ensures scientifically-guided treatment for couples at risk of genetic issues.
(Primary SEO Keywords: Preimplantation Genetic Diagnosis Nashik, PGT in Nashik, Genetic screening IVF Nashik, IVF genetic testing Nashik)
What is Preimplantation Genetic Diagnosis (PGD/PGT)?
PGD/PGT is an advanced ART technique that evaluates embryo health before uterine transfer. After embryos are created through IVF, a few cells are safely biopsied from each embryo. Those cells are analyzed for genetic and chromosomal abnormalities.
This allows physicians to transfer embryos that are:
- Genetically normal
- Less likely to miscarry
- Healthier for future pregnancy and child outcome
Unlike traditional IVF — which does not assess embryo genetics — PGD/PGT offers a targeted approach to maximize success and minimize risk.
Who Should Consider PGD/PGT in Nashik?
PGD is recommended for couples with:
✔ Known Genetic Conditions
- Parents carrying genetic mutations (e.g., Thalassemia, SMA, Cystic Fibrosis)
✔ Recurrent Pregnancy Loss
- Multiple miscarriages due to chromosomal abnormalities
✔ Advanced Maternal Age
- Reduced egg quality with age increases aneuploidy risk
✔ Previous IVF Failure
- Failed implantation without clear diagnosis
✔ Severe Male Factor Infertility
- High sperm abnormalities leading to poor embryo quality
✔ Unexplained Infertility
- When standard treatments aren’t identifying underlying embryo issues
Types of Genetic Screening
1. PGT-A (Aneuploidy Screening)
Checks if embryos have the correct number of chromosomes
Useful for:
- Recurrent miscarriage
- Advanced maternal age
2. PGT-M (Monogenic / Single Gene Disorders)
Detects specific inherited genetic conditions
Essential when:
- Parents are carriers of a known mutation
3. PGT-SR (Structural Rearrangement)
Used when one partner carries chromosomal rearrangements
Helps reduce embryo abnormality risk
How PGD/PGT Works – Step by Step
Step 1: IVF Stimulation & Egg Retrieval
Female partner undergoes controlled ovarian stimulation to produce multiple eggs.
Step 2: Fertilization (ICSI)
Fertilization is performed in the lab, often using ICSI to maximize fertilization success.
Step 3: Embryo Culture
Embryos are cultured to the blastocyst stage (Day 5–6).
Step 4: Embryo Biopsy
A few cells from each embryo are carefully removed using micromanipulation — a safe and standardized medical step.
Step 5: Genetic Analysis
Biopsied cells are tested using advanced genetic platforms:
- NGS (Next-Generation Sequencing)
- Array CGH
- PCR (where applicable)
Step 6: Embryo Selection and Transfer
Genetically normal embryos are selected and transferred into the uterus.
Step 7: Pregnancy Support & Confirmation
Follow-up monitoring and pregnancy testing complete the cycle.
Clinical Advantages of PGD/PGT
🧬 Higher Implantation Rates
Accurate embryo selection improves pregnancy chances.
🧬 Reduced Miscarriage Risk
Abnormal embryos are identified and not transferred.
🧬 Targeted Genetic Prevention
Reduces risk of inherited disorders.
🧬 Improved Live Birth Outcomes
Healthier embryos support healthier pregnancies
Success & Safety Considerations
PGD/PGT does not guarantee pregnancy — but significantly improves outcomes in selected couples.
Success depends on:
- Maternal age
- Quality of eggs and sperm
- Embryo development
- Laboratory standards
At Atharva Infertility Centre:
✔ Genetic testing is performed in collaboration with certified labs
✔ Embryo biopsy is conducted by experienced embryologists
✔ Results are interpreted with reproductive genetic specialists
Preimplantation Genetic Diagnosis: Myths vs Facts
PGD guarantees pregnancy |
Biopsy harms embryos |
Only for expensive treatment |
Genetic testing is only for old age |
No, but it improves chances |
Modern biopsy techniques are safe |
It’s recommended based on medical need |
Not true — any carrier risk situation benefits from PGD |
Who Benefits Most from PGD/PGT in Nashik
Ideal Candidates:
✔ Couples with family genetic history
✔ Couples with multiple miscarriages
✔ IVF failure cases
✔ Couples wishing to reduce risk of chromosomal abnormalities
✔ Age > 35 with fertility challenges
How PGD/PGT Improves IVF Journey
- Reduces emotional stress of failed cycles
- Provides data-driven embryo selection
- Offers genetic peace of mind
- Improves IVF planning and success projection
Frequently Asked Questions (FAQs)
Q1: Is PGD the same as genetic screening?
A: PGD is a type of genetic screening done before embryo transfer, focusing on embryo genetics — different from prenatal screening.
Q2: Does PGD harm embryos?
A: Modern embryo biopsy is safe, standardized, and does not affect development.
Q3: How long does PGD testing take?
A: Results are typically available within 1–2 weeks post biopsy.
Q4: Is PGD covered by insurance?
A: Genetic testing coverage varies — most fertility coverage is not standard; check your policy.
Q5: What is the cost of PGD in Nashik?
A: Costs vary based on lab technique (NGS, PCR, etc.); a consultation gives accurate estimates.
Why Atharva Infertility Centre for PGD/PGT in Nashik?
- International-standard IVF & genetic labs
Experienced reproductive endocrinologists
Certified embryologists skilled in embryo biopsy
Personalized genetic counseling
Transparent treatment plans and cost breakdown
Ongoing emotional and medical support
We provide a comprehensive patient experience—from pre-test counseling to post-transfer follow-up.
ICSI + PGD Combo – When It’s Most Effective
In most genetic testing cases, ICSI is recommended before biopsy because:
- Fertilization needs controlled precision
- Genetic testing requires day-5 blastocyst biopsy
- ICSI reduces risk of mixed embryo cell contribution
This ensures more reliable genetic results.
